The latest from NuvOx

Sep 27, 2020

Treatment of Swine Closed Head Injury with Perfluorocarbon

NanO2 may assist in mitigating secondary cellular brain damage after traumatic brain injury.

Feb 12, 2020

Welcoming the New Kid on the Block; A Phase IIb Study of DDFPe in Large Vessel Strokes

The design for an efficient Phase IIb clinical trial in stroke to test DDFPe in patients with Large Vessel Occlusions.

Nov 11, 2019

A Phase Ib/II clinical trial of DDFPe as a radiosensitizer in glioblastoma

Although small, this trial shows that DDFPe used as a radiosensitizer appears to be safe and may provide some survival benefit.

Aug 28, 2019

Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Trial

This randomized, placebo-controlled, double-blind, dose-escalation clinical trial in acute ischemic stroke patients was designed to...

Mar 1, 2019

Imaging assessment of cardioprotection mediated by DDFPe administered during myocardial infarction

DDFPe treatment in rats with myocardial infarction was associated by significantly reduced ischemia-reperfusion injury.

Feb 28, 2019

NuvOx Pharma’s NanO2 Shows Positive Results in Phase Ib/II Stroke Trial

Positive results of NuvOx Pharma’s NanO2 (DDFPe) in the treatment of stroke have been published at the International Stroke Conference. A...

Jan 29, 2019

In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

DDFPe efficiently offloads oxygen to hypoxic environments. Link to publication

Nov 8, 2017

DDFPe as a Resuscitation Fluid for Hemorrhagic Shock and Traumatic Brain Injury: A Review

Animal studies, for both hemorrhagic shock and TBI, show promising effects of DDFPe as a resuscitation fluid.

Jul 11, 2017

DDFPe reduced secondary brain injury in a Swine Model of Traumatic Brain Injury

In this swine model of TBI, administration of DDFPe resulted in lower injury scores for spongiosis and ischemic neurons.

Aug 8, 2016

Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke

DDFPe reduces infarct volume and neurological function following anterior ischemic stroke.

Apr 16, 2016

TOLD MRI validation of reversal of tumor hypoxia in glioblastoma with a novel oxygen therapeutic

MRI scans indicated that oxygen breathing with DDFPe administration improved tumor oxygenation.

Mar 1, 2016

DDFPe increased cerebral oxygen tension after traumatic brain injury in rats.

DDFPe increased brain tissue oxygen tension following TBI in rats and should be evaluated further as a possible treatment for TBI.

Mar 1, 2016

Reversal of Tumor hypoxia following intravenous delivery of DDFPe

DDFPe results in a significant increase in intra-tumoral oxygen tension for up to 45 minutes in our pancreatic xenograft model in mice.

Nov 10, 2015

Dynamic Oxygenation Measurements Using a Phosphorescent Coating Window Chamber Model

Intravenous injection of DDFPe in mice with tumors increases tumor oxygen levels.

Oct 31, 2015

DDFPe Extends Window for tPA Therapy in a Rabbit Stroke Model

DDFPe significantly extends the time window for tPA therapy.

Feb 16, 2015

DDFPe delays and reduces MRI markers of infarction in a rat stroke model

DDFPe delays and reduces MRI markers of stroke in the early hours following vascular occlusion in a rat stroke model.

Feb 9, 2015

Multiple Applications of DDFPe Prevents Death in a Rabbit Stroke Model

Increasing the number of DDFPe applications was significant in reducing the incidence of premature death.

Feb 1, 2015

A preliminary PET evaluation of DDFPe effects on rabbit brain hypoxia in stroke

DDFPe alleviates hypoxia in areas of ischemia.

Feb 1, 2015

Radiosensitization of Hs-766T Pancreatic Tumor Xenografts in Mice Dosed with DDFPe

DDFPe administration in mice with pancreatic tumor xenografts resulted in increased tumor oxygen tension lasting up to two hours.

Dec 30, 2014

DDFPe Decreases Stroke Size and Improves Neurological Scores in a Rat Stroke Model

DDFPe treatment provides significant neuroprotection when assessed six hours post stroke.