Publications

Treatment of Swine Closed Head Injury with Perfluorocarbon

NanO2 may assist in mitigating secondary cellular brain damage after traumatic brain injury.

Welcoming the New Kid on the Block; A Phase IIb Study of DDFPe in Large Vessel Strokes

The design for an efficient Phase IIb clinical trial in stroke to test DDFPe in patients with Large Vessel Occlusions.

A Phase Ib/II clinical trial of DDFPe as a radiosensitizer in glioblastoma

Although small, this trial shows that DDFPe used as a radiosensitizer appears to be safe and may provide some survival benefit.

Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Trial

This randomized, placebo-controlled, double-blind, dose-escalation clinical trial in acute ischemic stroke patients was designed to...

Imaging assessment of cardioprotection mediated by DDFPe administered during myocardial infarction

DDFPe treatment in rats with myocardial infarction was associated by significantly reduced ischemia-reperfusion injury.

NuvOx Pharma’s NanO2 Shows Positive Results in Phase Ib/II Stroke Trial

Positive results of NuvOx Pharma’s NanO2 (DDFPe) in the treatment of stroke have been published at the International Stroke Conference. A...

In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

DDFPe efficiently offloads oxygen to hypoxic environments. Link to publication

DDFPe as a Resuscitation Fluid for Hemorrhagic Shock and Traumatic Brain Injury: A Review

Animal studies, for both hemorrhagic shock and TBI, show promising effects of DDFPe as a resuscitation fluid.

DDFPe reduced secondary brain injury in a Swine Model of Traumatic Brain Injury

In this swine model of TBI, administration of DDFPe resulted in lower injury scores for spongiosis and ischemic neurons.

Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke

DDFPe reduces infarct volume and neurological function following anterior ischemic stroke.

TOLD MRI validation of reversal of tumor hypoxia in glioblastoma with a novel oxygen therapeutic

MRI scans indicated that oxygen breathing with DDFPe administration improved tumor oxygenation.

DDFPe increased cerebral oxygen tension after traumatic brain injury in rats.

DDFPe increased brain tissue oxygen tension following TBI in rats and should be evaluated further as a possible treatment for TBI.

Reversal of Tumor hypoxia following intravenous delivery of DDFPe

DDFPe results in a significant increase in intra-tumoral oxygen tension for up to 45 minutes in our pancreatic xenograft model in mice.

Dynamic Oxygenation Measurements Using a Phosphorescent Coating Window Chamber Model

Intravenous injection of DDFPe in mice with tumors increases tumor oxygen levels.

DDFPe Extends Window for tPA Therapy in a Rabbit Stroke Model

DDFPe significantly extends the time window for tPA therapy.

DDFPe delays and reduces MRI markers of infarction in a rat stroke model

DDFPe delays and reduces MRI markers of stroke in the early hours following vascular occlusion in a rat stroke model.

Multiple Applications of DDFPe Prevents Death in a Rabbit Stroke Model

Increasing the number of DDFPe applications was significant in reducing the incidence of premature death.

A preliminary PET evaluation of DDFPe effects on rabbit brain hypoxia in stroke

DDFPe alleviates hypoxia in areas of ischemia.

Radiosensitization of Hs-766T Pancreatic Tumor Xenografts in Mice Dosed with DDFPe

DDFPe administration in mice with pancreatic tumor xenografts resulted in increased tumor oxygen tension lasting up to two hours.

DDFPe Decreases Stroke Size and Improves Neurological Scores in a Rat Stroke Model

DDFPe treatment provides significant neuroprotection when assessed six hours post stroke.

Effects of DDFPe on cerebral microvasculature in the healthy rat.

asoconstriction in cerebral pial arterioles of healthy rats.

DDFPe Elicits Cardiac Protection Against Myocardial Infarction

Rats given DDFPe see a 72% reduction in myocardial infarct volume at 24 hours.

Progress in Dodecafluoropentane Emulsion as a Neuroprotective Agent in a Rabbit Stroke Model

Intravenous DDFPe decreases ischemic stroke infarct volumes. Rapid development is warranted.

Dodecafluoropentane Emulsion Decreases Infarct Volume in a Rabbit Ischemic Stroke Model

Intravenous DDFPe in an animal model decreases infarct volumes and protects brain tissue from ischemia justifying further investigation.

Hypoxia due to shunts in pig lung treated with DDFPe

19 pigs with depressed arterial oxygen tensions had DDFPe administered. DDFPe increased arterial, venous, and muscle oxygen tensions.

Basic mechanisms of gas transport and past research using perfluorocarbons

DDFPe improves the efficiency of oxygen exchange between blood and tissue. Link to publication

Development of a Minimal-Bulk Oxygen Delivery Product to Enhance Survival during Hemorrhagic Shock

US Army experiments concluding that DDFPe is a better resuscitation fluid then Hextend.

In Vitro Comparison of Dodecafluoropentane (DDFPe), Perfluorodecalin, and Perfluoroctylbromide

DDFPe absorbs more oxygen than other perfluorocarbon emulsions in-vitro.

DDFPe protects against fatal anemia in rats.

DDFPe treated rats see 100% survival at hemoglobin levels lower than what is fatal in 100% of controls.

Longterm survival of potentially lethal hemorrhagic shock after treatment with DDFPe

Pigs given 50% blood loss see 20% survival in controls (n=5) and 100% survival in those given DDFPe (n=5).